Brief report

Vol. 23 No. 6 (2025): Blood Transfusion 6-2025 (November-December)

Real world analysis of long-term efficacy of isovolemic red cell exchange in sickle cell disease: a single center experience

Authors

Key words: sickle cell disease, Hemodilution, exchange transfusion
Publication Date: 2025-05-22

Abstract

Automated Red Cell Exchange (RCE) using apheresis machines has been known since the 1980s. We implemented the IHD RCE strategy using SPECTRA OPTIA in mid-2021 during the Corona Viral Disease-19 (COVID-19) pandemic with the intention to decrease the number of PRBC units used, rather than increasing the time interval between sessions. This single-centre retrospective study demonstrated the sustainability of IHD over 2.5 years. While some patients required an increase in the number of PRBC units used at initiation, we demonstrated a durable 18.5% reduction in number of PRBC units used without any significant change in FCR at 2.5 years.

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Authors

Nikhil Vojjala Department of Internal Medicine, Trinity Health Oakland/Wayne State University School of Medicine, Pontiac, MI, United States of America

Rishab Prabhu Department of Internal Medicine, Trinity Health Oakland/Wayne State University School of Medicine, Pontiac, MI, United States of America

Janaka SS Liyanage Biostatistics and Bioinformatics Core, Department of Oncology, Wayne State University School of Medicine, Detroit, MI, United States of America

Dipen Kumar Modi Department of Hematology-Oncology Karmanos Cancer Institute/Wayne State University School of Medicine Detroit, MI, United States of America

Jay Yang Department of Hematology-Oncology Karmanos Cancer Institute/Wayne State University School of Medicine Detroit, MI, United States of America

Andrew Kin Department of Hematology-Oncology Karmanos Cancer Institute/Wayne State University School of Medicine Detroit, MI, United States of America

Indryas Woldie Department of Hematology-Oncology Karmanos Cancer Institute/Wayne State University School of Medicine Detroit, MI, United States of America

Asif Alavi Department of Hematology-Oncology, Henry Ford Health System, Detroit, MI, United States of America

Vijendra Singh Department of Hematology-Oncology Karmanos Cancer Institute/Wayne State University School of Medicine Detroit, MI, United States of America

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