Abstract
When unexpected antibodies recognizing self red blood cell antigens are detected in individuals by a positive direct antiglobulin (DAT) test and with no evidence of haemolytic anaemia, they are called ”silent red blood cell autoantibodies (SRBCAA)”. The role of placentally transferred allo- or autoantibodies is established but less is known about the antibodies transferred via breast milk. This is a case report of a 36-week premature female neonate born to a 38-year-old G2P1 with SRBCAA. The neonate presented with anaemia without signs of infection, hemolysis, or blood loss. The mother and neonate DATs were 1+. We identified the presence of an autoantibody against red cell antigens in the mother’s plasma and breast milk. A similar reaction pattern was also observed in the neonate plasma. The current case highlights the SRBAC detected in plasma and breast milk as a potential cause of haemolytic disease of the newborn.
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Authors
Zorica Radonjić
Department of Blood Transfusion, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia
Jelena Martić
Department of Neonatology, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia
Zorica Rakonjac
Department of Neonatology, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia
Nina Korać
Department for Pretransfusion Testing, Blood Transfusion Institute of Serbia, Belgrade, Serbia
Olivera Šerbić
Department of Blood Transfusion, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia
Martina Blagojević
Department of Blood Transfusion, Dr. Vukan Čupić Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia
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