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PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Abstract

Introduction
Alloimmunisation against the D antigen in pregnant RhD-negative women is preventable using anti-D immune prophylaxis1. A combination of antenatal and postnatal anti-D administration has dramatically reduced alloimmunisation of RhD negative women from 16% to 0.3%1,2. Analysis of cell-free foetal DNA (cffDNA) circulating in maternal plasma facilitates non-invasive antenatal testing of the foetal RhD genotype at an early gestational age3,4. Knowledge of the foetal RhD type allows targeted use of antenatal prophylaxis, avoiding unnecessary treatment of RhD-negative women who are carrying a RhD-negative foetus, and are thus at no risk of immunisation. [...]

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Authors

Frederik B. Clausen Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Angela N. Barrett Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Grethe R. Krog Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Kirstin Finning International Blood Group Reference Laboratory, NHS Blood and Transplant, Bristol, United Kingdom

Morten H. Dziegiel Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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