Register Login

PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Case report

Vol. 21 No. 5 (2023): Blood Transfusion 5-2023 (September-October)

Solid tumor transmission from donor to recipient after allogeneic stem cell transplantation: it is rare but it happens!

Authors

Panagiotis Tsirigotis , Alexandros Spyridonidis , Konstantinos Gkirkas , Spiros Chondropoulos , Phivi Rondogianni , Thomas Thomopoulos , Angeliki Karagiannidou , Dionysios Vythoulkas , Marianna Griniezaki , Nikolaos Georgakopoulos , Maria Stamouli , Periklis G. Foukas

Key words: solid tumor, allogeneic stem cell transplantation, donor origin
Doi: 10.2450/BloodTransfus.498
Hematopoietic stem cell transplantation and cord blood banking
Publication Date: 2023-03-10

Abstract

Preview

Introduction

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only therapeutic modality with a curative potential for various hematopoietic diseases. However, long term survivors remain at high risk of late complications, including the development of secondary solid malignancies. There is a limited amount of data, regarding the cell of origin and the pathogenesis of secondary solid malignancies post allo-SCT. Several hypotheses have been proposed such as, de-novo occurrence, progression of an occult pre-existing malignancy, and donor-cell related malignancy1.

In the present manuscript, we report a case of a secondary solid neoplasm developed post allo-SCT in a patient with acute myeloid leukemia (AML). An extensive laboratory evaluation for the elucidation of the origin of neoplastic cells is presented in detail.   

References

Downloads

pdf
Authors

Panagiotis Tsirigotis Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Alexandros Spyridonidis Department of Bone Marrow Transplantation, University Hospital of Rio Patras, Medical School, University of Patras, Greece

Konstantinos Gkirkas Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Spiros Chondropoulos Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Phivi Rondogianni Nuclear Medicine and PET/CT Department, Evangellismos General Hospital, Athens, Greece

Thomas Thomopoulos Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Angeliki Karagiannidou Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Dionysios Vythoulkas Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Marianna Griniezaki Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Nikolaos Georgakopoulos Department of Cytogenetics and Molecular Pathology, Locus Medicus S.A, Athens, Greece

Maria Stamouli Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

Periklis G. Foukas Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

  • Abstract viewed - 1152 times
  • pdf downloaded - 0 times